abstract：:Diabetic cardiomyopathy is a leading cause of morbidity and mortality, and Insulin2 mutant (Ins2+/-) Akita is a genetic mice model of diabetes relevant to humans. Dicer, miRNAs, and inflammatory cytokines are associated with heart failure. However, the differential expression of miRNAs, dicer, and inflammatory molecul...

journal_title：Cell biochemistry and biophysics

authors： Chavali V,Tyagi SC,Mishra PK

更新日期：2014-01-01 00:00:00

abstract：:3-Iodothyronamine (T1AM) is regarded as a hormone-like substance thanks to its endogenous nature, its interaction with specific receptors trace amine-associated receptor 1 and its biological effects. We characterized T1AM transport and conversion in an in vitro culture of H9c2 murine cells, after a T1AM bolus injectio...

journal_title：Cell biochemistry and biophysics

authors： Orsi G,Ghelardoni S,Saba A,Zucchi R,Vozzi G

更新日期：2014-01-01 00:00:00

abstract：:MicroRNAs (miRs) play important roles in initiation and progression of many pathologic processes. However, the roles of miRs in diabetic nephropathy remain unclear. This study was to determine whether miR-21 was involved in diabetic nephropathy and to explore the relationship between miR-21 and MMP9/TIMP1 expression i...

journal_title：Cell biochemistry and biophysics

authors： Wang J,Gao Y,Ma M,Li M,Zou D,Yang J,Zhu Z,Zhao X

更新日期：2013-11-01 00:00:00

abstract：:Early events in individual hepatocytes of rat activated by adrenaline (10(-6)M) and phenylephrine (10(-5)M) have been investigated by quantitative image microfluorometry and microspectrofluorometry. Cationic DiOC2 and anionic SqSC4 probes have been used for image analysis and transmembrane potential (ΔΨ p) estimation ...

journal_title：Cell biochemistry and biophysics

authors： Kavok NS,Malyukina MY,Borovoy IA,Obukchova EN,Klimov SA

更新日期：2013-11-01 00:00:00

abstract：:Circumstantial evidence frequently implicates oxygen-derived free radicals and oxidative stress as mediators of myocardial ischemia/reperfusion (I/R) injury. Therefore, external supplementation of natural antioxidants plays a main role as cardioprotective compounds. This study was designed to evaluate the cardioprotec...

journal_title：Cell biochemistry and biophysics

authors： Adluri RS,Thirunavukkarasu M,Zhan L,Maulik N,Svennevig K,Bagchi M,Maulik G

更新日期：2013-11-01 00:00:00

abstract：:Apoptosis of endothelial cells related to homocysteine (Hcy) has been reported in several studies. In this study, we evaluated whether reactive oxygen species (ROS)-producing signaling pathways contribute to Hcy-induced apoptosis induction, with specific emphasis on NADPH oxidases. Human umbilical vein endothelial cel...

journal_title：Cell biochemistry and biophysics

authors： Sipkens JA,Hahn N,van den Brand CS,Meischl C,Cillessen SA,Smith DE,Juffermans LJ,Musters RJ,Roos D,Jakobs C,Blom HJ,Smulders YM,Krijnen PA,Stehouwer CD,Rauwerda JA,van Hinsbergh VW,Niessen HW

更新日期：2013-11-01 00:00:00

abstract：:The airways in asthma and COPD are characterized by an increase in airway smooth muscle (ASM) mass and bronchial vascular changes associated with increased expression of pro-angiogenic growth factors, such as fibroblast growth factors (FGF-1 and FGF-2) and vascular endothelial growth factor (VEGF). We investigated the...

journal_title：Cell biochemistry and biophysics

authors： Willems-Widyastuti A,Vanaudenaerde BM,Vos R,Dilisen E,Verleden SE,De Vleeschauwer SI,Vaneylen A,Mooi WJ,de Boer WI,Sharma HS,Verleden GM

更新日期：2013-11-01 00:00:00

abstract：:Mechanical loading is known to promote osteocyte survival, whereas glucocorticoid treatment results in osteocyte apoptosis. Here, we report that BMP-7, which was secreted by osteocyte in response to mechanical loading, exerts anti-apoptotic effect against dexamethasone-induced apoptosis of osteocytes. We further show ...

journal_title：Cell biochemistry and biophysics

authors： Wang Z,Guo J

更新日期：2013-11-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) is the primary pathway responsible for the recognition and degradation of misfolded, damaged, or tightly regulated proteins in addition to performing essential roles in DNA repair, cell cycle regulation, cell migration, and the immune response. While traditional biochemical techni...

journal_title：Cell biochemistry and biophysics

authors： Melvin AT,Woss GS,Park JH,Waters ML,Allbritton NL

更新日期：2013-09-01 00:00:00

abstract：:Far from now are the days when investigators raced to identify the proteolytic system responsible for the degradation of their favorite protein. Nowadays, it is well accepted that a given protein can be degraded by different systems depending on factors such as cell type, cellular conditions, or functionality of each ...

journal_title：Cell biochemistry and biophysics

authors： Park C,Cuervo AM

更新日期：2013-09-01 00:00:00

abstract：:We report herein a 1.5-year-old girl with methylmalonic acidemia (MMA) in whom two missense mutations were found: a novel I739T mutation located in exon 13 and the L494X mutation in exon 8. The results of organic acid test showed a pronounced increase in methylmalonate excretion with increased methylcitrate and 3-OH-p...

journal_title：Cell biochemistry and biophysics

authors： Imataka G,Sakamoto O,Yamanouchi H,Yoshihara S,Omura-Hasegawa Y,Tajima G,Arisaka O

更新日期：2013-09-01 00:00:00

abstract：:Fibroblasts can be reprogrammed by ectopic expression of reprogramming factors to yield induced pluripotent stem (iPS) cells that are capable of transdifferentiating into diverse types of somatic cell lines. In this study, we examined if functional cardiomyocytes (CMs) can be produced from mouse cardiac fibroblasts (C...

journal_title：Cell biochemistry and biophysics

authors： Jiang B,Dong H,Li Q,Yu Y,Zhang Z,Zhang Y,Wang G,Zhang Z

更新日期：2013-06-01 00:00:00

abstract：:We have previously shown that plasma membrane calcium ATPase (PMCA) pump activity is affected by the membrane protein concentration (Vanagas et al., Biochim Biophys Acta 1768:1641-1644, 2007). The results of this study provided evidence for the involvement of the actin cytoskeleton. In this study, we explored the rela...

journal_title：Cell biochemistry and biophysics

authors： Vanagas L,de La Fuente MC,Dalghi M,Ferreira-Gomes M,Rossi RC,Strehler EE,Mangialavori IC,Rossi JP

更新日期：2013-05-01 00:00:00

abstract：:Escherichia coli has four hydrogenases (Hyd), three genes of which are encoded by the hya, hyb, and hyc operons. The proton-reducing and hydrogen-oxidizing activities of Hyd-2 (hyb) were analyzed in whole cells grown to stationary phase and cell extracts, respectively, during glycerol fermentation using novel double m...

journal_title：Cell biochemistry and biophysics

authors： Trchounian K,Soboh B,Sawers RG,Trchounian A

更新日期：2013-05-01 00:00:00

abstract：:The dynamic micromechanical and structural properties of single human red blood cells are studied using a combination of dual trap optical tweezers and confocal Raman spectroscopy. Such a combination permits us to show a direct relationship between the rheological properties and chemical structure conformation. The fr...

journal_title：Cell biochemistry and biophysics

authors： Raj S,Wojdyla M,Petrov D

更新日期：2013-04-01 00:00:00

abstract：:There is an emergent need for improving the microsurgical technique of variant arterial anastomosis to reduce the often seen surgery-related complications. We describe in this article our experience in improving this technique, in 73 living donor liver grafts (64 right lobes, 9 left lobes) in patients with end-stage l...

journal_title：Cell biochemistry and biophysics

authors： Liang Y,Ye S,Shi X,Ji W,Duan W,Luo Y,Dong J

更新日期：2013-03-01 00:00:00

abstract：:Previous studies have shown that A. lumbricoides extracts capture sialic acid (SA) from human red blood cells (RBC). The aim of this work was to study hemorheological alterations in vitro caused by parasite larvae. The biorheological action of three larva concentrates of first and second larval stage on group O erythr...

journal_title：Cell biochemistry and biophysics

authors： de León PP,Del Balzo G,Riquelme B

更新日期：2013-03-01 00:00:00

abstract：:Either the role of the adaptive immune system or the interaction between innate and adaptive immune systems in familial Mediterranean fever (FMF) is not clear so far. So, we planned to search for the interaction between the innate and adaptive immune systems in the pathogenesis of FMF by investigating polymorphism for...

journal_title：Cell biochemistry and biophysics

authors： Gunesacar R,Erken E,Dinkci S

更新日期：2013-03-01 00:00:00

abstract：:Leptin is a protein hormone which plays a critical role in the regulation of both body-weight through reducing food intake and stimulating energy expenditure. Several polymorphisms in leptin gene (LEP), which encodes for leptin, have been described. However, its association with obesity is still controversial. Therefo...

journal_title：Cell biochemistry and biophysics

authors： Sahin DS,Tumer C,Demir C,Celik MM,Celik M,Ucar E,Gunesacar R

更新日期：2013-03-01 00:00:00

abstract：:Cadmium (Cd) is a potent toxic element used in several industries and in the process contaminates air, soil, and water. Exposure of Saccharomyces cerevisiae to Cd increases the major phospholipids, and profound increase was observed in phosphatidylethanolamine (PE). In yeast, there are four different pathways contribu...

journal_title：Cell biochemistry and biophysics

authors： Muthukumar K,Nachiappan V

更新日期：2013-01-01 00:00:00

abstract：:A rapid and sensitive liquid chromatography-tandem mass spectrometry assay (LC-MS/MS) with electrospray ionization was developed and validated for the quantitative determination of the concentration of methotrexate (MTX) enantiomers in intracellular and extracellular fluids of HepG2 cells. The analytes were extracted ...

journal_title：Cell biochemistry and biophysics

authors： Wang R,Guo L,Xie H,Zhang J,Li X,Li W,Wang J,Wu X,Jia Z

更新日期：2013-01-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) are of great interest for regenerative purposes since they are believed to aid axonal growth. With the view set on the strategies to achieve reconnection between neuronal structures, it is of great importance to characterize the behaviour of these cells on long thread-like structures...

journal_title：Cell biochemistry and biophysics

authors： Pérez-Garnés M,Martínez-Ramos C,Barcia JA,Escobar Ivirico JL,Gómez-Pinedo U,Vallés-Lluch A,Monleón Pradas M

更新日期：2013-01-01 00:00:00

abstract：:Characterization of the electroclinical features and evolution of childhood occipital epilepsy of Gastaut (COE-G). Seven children were retrospectively identified as having COE-G and were followed-up clinically using EEGs. Visual manifestations were the most common ictal event. Eye-associated ictal deviation was associ...

journal_title：Cell biochemistry and biophysics

authors： Shu XM,Zhang GP,Yang BZ,Li J

更新日期：2013-01-01 00:00:00

abstract：:To reveal protective role of the new Mn(II) complexes with Nicotinyl-L-Tyrosinate and Nicotinyl-L-Tryptophanate Schiff Bases against ionizing radiation. The DNA of the rats liver was isolated on 7, 14, and 30 days after X-ray irradiation. The differences between the DNA of irradiated rats and rats pre-treated with Mn(...

journal_title：Cell biochemistry and biophysics

authors： Karapetyan NH,Malakyan MH,Bajinyan SA,Torosyan AL,Grigoryan IE,Haroutiunian SG

更新日期：2013-01-01 00:00:00

abstract：:We evaluated the relationship between cellular gap junction and bystander effect in gastric cancer SCG7901 cell killing by adenovirus-mediated KDR-CDglyTK system. SCG7901 and HeLa cells were transfected (MOI-100) with recombinant adenovirus carrying fusion gene. Transfection efficiency/fusion gene mRNA expression were...

journal_title：Cell biochemistry and biophysics

authors： Qiang L,Yanping L,Zonghai H,Fei C,Zhou L,Jinlong Y

更新日期：2013-01-01 00:00:00

abstract：:In previous work, decolorization of malachite green (MG) was studied in Aspergillus niger in the presence and absence of calcium chloride stress. Decolorization took place within 24 h, and a signal transduction process that initiated MG decolorization was suggested to be involved. In the present study, further investi...

journal_title：Cell biochemistry and biophysics

authors： Gomaa OM,Selim NS,Linz JE

更新日期：2013-01-01 00:00:00

abstract：:The aim of the present work is to evaluate the effect of caffeine, the world's most popular psychoactive drug, on the electric activity of the rat's brain that exposed to extremely low-frequency magnetic field (ELF-MF), during 15 days. The obtained results showed that administration of caffeine in a group of rats by d...

journal_title：Cell biochemistry and biophysics

authors： El Gohary MI,Salama AA,El Saeid AA,El Sayed TM,Kotb HSh

更新日期：2013-01-01 00:00:00

abstract：:Non-esterified fatty acids (NEFAs) act as signaling molecules involved in regulating genes expression to modulate lipid metabolism. However, the regulation mechanism of NEFAs on lipid metabolism in dairy cows is unclear. The AMP-activated protein kinase (AMPK) signaling pathway plays a key role in regulating hepatic l...

journal_title：Cell biochemistry and biophysics

authors： Li X,Li X,Chen H,Lei L,Liu J,Guan Y,Liu Z,Zhang L,Yang W,Zhao C,Fu S,Li P,Liu G,Wang Z

更新日期：2013-01-01 00:00:00

abstract：:Molecular motors are responsible of transporting a wide variety of cargos in the cytoplasm. Current efforts are oriented to characterize the biophysical properties of motors in cells with the aim of elucidating the mechanisms of these nanomachines in the complex cellular environment. In this study, we present an algor...

journal_title：Cell biochemistry and biophysics

authors： Bruno A,Bruno L,Levi V

更新日期：2013-01-01 00:00:00

abstract：:Several single nucleotide polymorphisms (SNPs) within the CTLA-4 gene and elevated serum levels of soluble CTLA-4 (sCTLA-4) have been associated with autoimmunity including rheumatoid arthritis (RA). In this case-control study, we evaluated the relationship between the -319C/T (rs5742909) and CT60 G/A (rs3087243) SNPs...

journal_title：Cell biochemistry and biophysics

authors： Torres-Carrillo N,Ontiveros-Mercado H,Torres-Carrillo NM,Parra-Rojas I,Rangel-Villalobos H,Ramírez-Dueñas MG,Gutiérrez-Ureña SR,Valle Y,Muñoz-Valle JF

更新日期：2013-01-01 00:00:00

abstract：:Ezrin is overexpressed in a variety of neoplastic cells and is involved in the later stages of tumor progression and metastasis. The present study investigated the expression and functional significance of ezrin in human brain astrocytoma. Ezrin expression was examined in specimens from healthy human brains (10 autops...

journal_title：Cell biochemistry and biophysics

authors： Mao J,Yuan XR,Xu SS,Jiang XC,Zhao XT

更新日期：2013-01-01 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) refer to those proteins without fixed three-dimensional structures under physiological conditions. Although experiments suggest that the conformations of IDPs can vary from random coils, semi-compact globules, to compact globules with different contents of secondary structures,...

journal_title：Cell biochemistry and biophysics

authors： Zhang T,Faraggi E,Li Z,Zhou Y

更新日期：2013-01-01 00:00:00

abstract：:Epidemiologic and experimental studies suggest that dietary fatty acids influence the development and progression of breast cancer. However, no clear data are present in literature that could demonstrate how n - 3 PUFA can interfere with breast cancer growth. It is suggested that these fatty acids might change the str...

journal_title：Cell biochemistry and biophysics

authors： Corsetto PA,Cremona A,Montorfano G,Jovenitti IE,Orsini F,Arosio P,Rizzo AM

更新日期：2012-09-01 00:00:00

abstract：:In recent studies, sulforaphane (SFN) has been seen to demonstrate antioxidant and anti-tumor activities as well as potent chemopreventive action against cancer. The present study investigates the anti-proliferation (using MTT assay, SFN demonstrated cytotoxic activity against GBM 8401 cell with IC(50) values at 35.52...

journal_title：Cell biochemistry and biophysics

authors： Huang TY,Chang WC,Wang MY,Yang YR,Hsu YC

更新日期：2012-07-01 00:00:00

abstract：:A Caulimovirus-based hybrid-promoter, EFCFS, was derived by fusing the distal region (-227 to -54, FUAS) of Figwort mosaic virus full-length transcript promoter (F20) with the core promoter (-151 to +12, FS3CP) domain of Figwort mosaic virus sub-genomic transcript promoter (FS3). The hybrid-promoter (EFCFS) showed enh...

journal_title：Cell biochemistry and biophysics

authors： Ranjan R,Dey N

更新日期：2012-07-01 00:00:00

abstract：:Intensive treatment for newborns with trisomy 13 is controversial because of their lethal prognosis. We report the better life prognosis of patients with trisomy 13 who received intensive treatment. At our hospital, we provided an intensive management to such patients including resuscitation and surgical procedures as...

journal_title：Cell biochemistry and biophysics

authors： Tsukada K,Imataka G,Suzumura H,Arisaka O

更新日期：2012-07-01 00:00:00

abstract：:Human copper transporter 1 (hCTR1) is the major high affinity copper influx transporter in mammalian cells that also mediates uptake of the cancer chemotherapeutic agent cisplatin. A low resolution structure of hCTR1 determined by cryoelectron microscopy was recently published. Several protein structure simulation tec...

journal_title：Cell biochemistry and biophysics

authors： Tsigelny IF,Sharikov Y,Greenberg JP,Miller MA,Kouznetsova VL,Larson CA,Howell SB

更新日期：2012-07-01 00:00:00

abstract：:Mechanics of cancer cells are directly linked to their metastatic potential, or ability to produce a secondary tumor at a distant site. Metastatic cells survive in the circulatory system in a non-adherent state, and can squeeze through barriers in the body. Such considerable structural changes in cells rely on rapid r...

journal_title：Cell biochemistry and biophysics

authors： Gal N,Weihs D

更新日期：2012-07-01 00:00:00

abstract：:We have examined the association of insulin receptors (IR) and downstream signaling molecules with membrane microdomains in rat basophilic leukemia (RBL-2H3) cells following treatment with insulin or tris(2-pyridinecarbxylato)chromium(III) (Cr(pic)(3)). Single-particle tracking demonstrated that individual IR on these...

journal_title：Cell biochemistry and biophysics

authors： Al-Qatati A,Winter PW,Wolf-Ringwall AL,Chatterjee PB,Van Orden AK,Crans DC,Roess DA,Barisas BG

更新日期：2012-04-01 00:00:00

abstract：:Spectral karyotyping is a novel technique for chromosome analysis that has been developed based on the approach of the fluorescence in situ hybridization technique. Spectral karyotyping makes it feasible to diagnose a variety of diseases, because of its technology in painting each of the 24 human chromosomes with diff...

journal_title：Cell biochemistry and biophysics

authors： Imataka G,Arisaka O

更新日期：2012-01-01 00:00:00